Analytical and characterisation data for salicylaldehyde-based ligands and corresponding copper complexes
Publication Date
August 12, 2026
Description
The data includes NMR, MS and CHN data for novel salicylaldehyde ligands and MS, EPR and UV-vis data for thier corresponding copper complexes, alongside crystallographic cif reports for both ligands and complexes (when single cystals could be obtained).
Copper-based compounds have long been explored for their anti-cancer potential and other biological effects. While positive results have been reported, their use as cytotoxic agents remains limited; additionally, novel ligands and complexes could provide alternative strategies for cancer treatment. In this work, we synthesised three Schiff base ligands and their corresponding copper(II) complexes; the ligands included a non-substituted, an electron withdrawing or an electron donating substituent positioned para to the Cu-coordinating hydroxyl group to evaluate how these modifications might influence cytotoxicity. The complexes were assessed against highly invasive glioblastoma (GBM) cells grown in both 2D monolayers and 3D spheroid models. GBM is a grade 4 brain tumour with an extremely poor prognosis, and patient survival has shown little improvement over the past two decades, underscoring the urgent need for new therapeutic strategies.
Associate publ. Title
Copper complexes as candidate therapeutic agents against infiltrative glioblastoma cells
Subjects
Subjects (LC)
Divisions
Data type
Other
Funders
University of Nottingham
Data collection method
Experiment::Laboratory experiment
Legal and ethical issues
Chemical andd analytical experimental data collected by the PI or PhD student working on the project. No sensitive or personal data are included in this dataset
Resource languages
English (UK)
Publisher
University of Nottingham
Date Issued
January 31, 2027
Except where otherwise noted, this item's license is described as
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