Modelling of N-carboxy anhydride copolymerisations for improved sequence control of poly(amino acid)s in bioengineering applications
Publication Date
July 31, 2022
Creator
Abstract
Synthetically manufactured poly(amino acid)s have been exploited in a variety of bioengineering applications including antimicrobial surfaces and cell culture substrates because of their ability to display functionality linked to secondary structure formation. This functionality is closely connected to the sequence of the amino acids in the poly(amino acid) chains. N-carboxy anhydride (NCA) polymerisation is an attractive route to manufacture poly(amino acid)s but it lacks sequence control. Furthermore, experimental sequence analysis of poly(amino acid)s is challenging. Computational methods are an attractive alternative to obtain sequence related information but few computational copolymerisation models exist for this purpose and none have been designed for NCA polymerisations.
Item Type
ethesis
Thesis Type
MRes
Supervisors
Subjects (LC)
Associated Schools / Departments
School of Veterinary Medicine and Science
eprints ID
71591
UoN Repository URI
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MRes_Thesis_Mischa_Zelzer_2022_final_corr_221210.pdf
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Full-text
Description
Examined
Size
9.34 MB
Format
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