MRS studies of the effects of dietary interventions on hepatic metabolism

Bawden, Stephen

MRS studies of the effects of dietary interventions on hepatic metabolism

Publication Date

December 9, 2014

Creator

Bawden, Stephen

Abstract

Magnetic Resonance Spectroscopy is a powerful non-invasive tool for investigating liver metabolism in vivo. PRESS and STEAM localized 1H MRS can be used to provide liver lipid measurements calculated from the fat to water peak ratios. Surface coils can also be used to measure other metabolites using multinuclear MRS, 13C MRS directly measures glycogen levels and 31PMRS measures ATP and other phosphate metabolites. This thesis reports on studies undertaken to develop these techniques and describes a number of in vivo investigations that explored the effects of dietary interventions on hepatic metabolism.

Item Type

ethesis

Thesis Type

PhD

Supervisors

Gowland, Penny

Marciani, Luca

Morris, Peter

Subjects (LC)

QC Physics::QC501 Ele...

QP Physiology::QP1 Ph...

Associated Schools / Departments

School of Physics and Astronomy

eprints ID

30390

UoN Repository URI

https://repository.nottingham.ac.uk/handle/123456789/33733

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Name

ThesisSJB_hardbound121114.pdf

Type

Full-text

Description

Examined

Size

4.52 MB

Format

Adobe PDF

Checksum (MD5)

877fb744b9a394892b755944ab4034f3