Antimicrobials and antimicrobial resistance

Smith, Frances

Antimicrobials and antimicrobial resistance

Publication Date

December 12, 2017

Creator

Smith, Frances

Abstract

Drug discovery and development is becoming increasingly harder due to scientific bottlenecks, increased regulation from approval bodies and economic circumstance. Using unusual approaches to drug discovery can fast-track the production of new antimicrobials, as is the case with drug repurposing. There is a strong need for antimicrobial agents that bacteria can’t develop resistance to and the best way to address this is by developing drugs that do not create a strong selection for resistance. Antivirulence drugs are ideal in this respect as they do not target essential biological processes. It is naïve, however, to assume that bacteria will never develop resistance to any of the antibiotics they are presented with. Careful control over the use of antibiotics should be employed to prevent the development and spread of resistance if we are to avoid the upcoming antibiotic apocalypse.

Item Type

ethesis

Thesis Type

MRes

Supervisors

Williams, P.

Keywords

Antimicrobial resista...

molecular microbiolog...

drug screening

Subjects (LC)

QR Microbiology::QR17...

Associated Schools / Departments

School of Life Sciences

eprints ID

48053

UoN Repository URI

https://repository.nottingham.ac.uk/handle/123456789/29497

Except where otherwise noted, this item's license is described as

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Name

Smith_Frances_MResThesis_FinalandRevised_Confidential.pdf

Type

Full-text

Description

Examined

Size

7.24 MB

Format

Adobe PDF

Checksum (MD5)

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Name

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