Ultrasound determinants of endometrial receptivity
Publication Date
July 17, 2024
Creator
Abstract
This thesis is a study of “the prognostic accuracy of endometrial patterns on ultrasound to predict implantation”. I hypothesised that endometrial pattern on ultrasound can predict and help improve the outcome of in vitro fertilisation (IVF).
I performed a systematic review and meta-analysis on the prognostic accuracy of endometrial patterns on ultrasound to predict implantation. It showed that women with triple pattern at trigger are more likely to become pregnant when compared to women with a homogenous pattern. Similarly, women with a homogenous pattern at fresh embryo transfer were more likely to become pregnant compared to women with an intermediate pattern. However, this is limited by the low to moderate quality evidence of some of the studies, and is also limited by the substantial heterogeneity of the studies and the different classification systems. (Chapter 2)
In chapter 3, in review of the literature and from day to day scanning and along with my own observation, I developed the “endometrial pattern recognition” classification system. I tested the reliability of the old classification system. I taught and introduced the new classification system and tested its reliability. The old classification system showed substantial agreement between observers while the new classification system showed moderate to substantial agreement.
In chapter 4, I performed a “prognostic accuracy study” of endometrial patterns on ultrasound to predict implantation using our novel classification system. The results of this showed that women with a homogenous pattern at egg collection were less likely to become pregnant when compared to women with a triple pattern. It also showed that women with late intermediate pattern at egg collection were less likely to become pregnant when compared to women with a triple pattern (clinical pregnancy OR 0.65, 95% CI 0.21 to 1.98). These results are statistically significant with a p value of <0.05 However, there are some limitations and larger studies are need to validate these results.
In chapter 5, I performed a study to explore the relationship between the endometrial pattern on ultrasound, histology and microarray. This showed that there is a positive correlation between histology and ultrasound endometrial patterns on principle component analysis plots.
Item Type
ethesis
Thesis Type
PhD
Subjects (LC)
Associated Schools / Departments
Division of Medical Sciences and Graduate Entry Medicine
eprints ID
77196
UoN Repository URI
Except where otherwise noted, this item's license is described as
File(s)![Thumbnail Image]()
Name
Ultrasound Determinants of endometrial receptivity minor corrections updated version.pdf
Type
Full-text
Description
Examined. Updated thesis with minor corrections
Size
3.35 MB
Format
Adobe PDF
Checksum (MD5)
fc43de1877d11e619047295512fb0cb6