Synthesis of pyrroles by nickel-catalysed arylative cyclisations of alkynamides
Publication Date
July 17, 2019
Creator
Abstract
A nickel-based catalytic system for the anti-carbometallative cyclisations of alkynamides to arylboronic acids is described. The reactions proceed using catalytic nickel and (rac)-Ph-PHOX, to provide alkenylnickel species which can undergo reversible E/Z-isomerisation, followed by cyclisation onto an N-tosylamide to give 2,3,4-trisubstituted pyrroles.
Pyrroles are of widespread chemical significance, being present in numerous biologically active natural products. This methodology was used to generate a series of multisubstituted pyrroles and perform concise syntheses of BODIPY derivative and pyrrolyl propionic acid.
Item Type
ethesis
Thesis Type
MScRes
Supervisors
Subjects (LC)
Associated Schools / Departments
School of Chemistry
eprints ID
55874
UoN Repository URI
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