New chemistry to support the search for more effective opioids
Publication Date
May 27, 2020
Creator
Abstract
Herein is presented a synthesis route to obtain noroxymorphone, a vital intermediate in the manufacture of opioid medicines, using the major ingredient in opium – morphine as the starting material. Two steps of Albright-Goldman oxidation and the formation of diene are combined in one pot to enhance the efficiency of the whole route. The overall 14% yield is still impractical for industry. However, further optimization of Albright-Goldman oxidation can increase the yield to near 30% in total. Noroxymorphone is employed as a starting material to access new opioid derivatives by N-substitution or conjugate addition of amines onto electron-deficient alkenes.
Item Type
ethesis
Thesis Type
MScRes
Supervisors
Subjects (LC)
Associated Schools / Departments
School of Chemistry
eprints ID
60621
UoN Repository URI
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Ruoyan Thesis 14342401.pdf
Type
Full-text
Description
Examined
Size
2.55 MB
Format
Adobe PDF
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