Identification of novel survivin interactors
Publication Date
December 11, 2024
Creator
Abstract
Survivin, a multifaceted protein, plays crucial roles in various cellular
processes, including apoptosis inhibition, mitosis, autophagy, and mitochondrial dynamics.Its overexpression has been linked to cancer cell proliferation, angiogenesis, chemotherapy resistance, and poor prognosis in multiple sclerosis. While primarily known for its roles in programmed cell death and cell division, recent evidence suggests its involvement in clathrin-mediated endocytosis trafficking.
To explore survivin's interactions and potential functions, we conducted protein-protein interaction studies. We identified two novel interactors, AP1g1 and Seh1, and confirmed a previously reported interaction with CHC. Our findings indicate that survivin directly interacts with AP1g1 and Seh1, while its interaction with CHC is indirect. Additionally, we observed that survivin overexpression downregulates the expression of CNP and PDGFR-a, two myelin-related genes regulated by Seh1 indicating a potential survivin role.These results collectively suggest that survivin may play a role in trafficking and in regulating the myelination of the central nervous system.
Item Type
ethesis
Thesis Type
PhD
Supervisors
Subjects (LC)
Associated Schools / Departments
School of Life Sciences
eprints ID
79899
UoN Repository URI
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Name
Alhawsaw, Naif, 2013261, Correction Submession.pdf
Type
Full-text
Description
Examined. Corrections
Size
28.39 MB
Format
Adobe PDF
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