New methods for the arylation of trivalent phosphorus species
and Studies towards the synthesis of sesqui-lignan natural products
Publication Date
July 18, 2017
Creator
Abstract
Chapter one describes two efficient synthesis methods for the preparation of functionalised phosphonium salts. The first method utilises aryl radicals generated by a photo-induced decomposition of diaryliodonium salts, with the second method generating aryl radicals from arylboronic acids and manganese acetate. In both cases a broad substrate scope is demonstrated with respect to both the phosphorus and arylating species.
Chapter two describes approaches to the total synthesis of plant sesqui-neolignans. The synthesis of macranthol was achieved in 5 steps from commercially available 4-allylanisole in 7% yield. As well as the first synthesis of the core [4.3.0] ring structure of the fargenin/fargenone family of natural products.
Item Type
ethesis
Thesis Type
PhD
Supervisors
Subjects (LC)
Associated Schools / Departments
School of Chemistry
eprints ID
42420
UoN Repository URI
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Name
Adam Fearnley Thesis.pdf
Type
Full-text
Description
Examined
Size
4.58 MB
Format
Adobe PDF
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