One Pot Silane Mediated Reductive Amination using Methyl Esters as Nominal Electrophiles
Publication Date
July 24, 2024
Creator
Abstract
Reductive aminations are a commonly employed method of C−N bond formation with a quarter of C−N bond formations in pharmaceutical synthesis performed via a reductive amination. Conventional reductive amination reactions rely on aldehydes as electrophiles which can be difficult to handle as a result of aldol dimerisation and autooxidation. This poster describes a new class of reductive amination reaction in which readily available carboxylic acid esters are used as nominal electrophiles in place of aldehydes. The amination process involves organocatalytic amide formation followed by silane-mediated reduction of the derived amide. The thesis describes the optimisation, scope, and mechanism of this novel amination protocol.
Item Type
ethesis
Thesis Type
MRes
Supervisors
Subjects (LC)
Associated Schools / Departments
School of Chemistry
eprints ID
78012
UoN Repository URI
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Name
thesis with corrections SAVE.pdf
Type
Full-text
Description
Examined
Size
2.47 MB
Format
Adobe PDF
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