File upload size is currently capped at 500MB. For assistance adding larger files, please contact discovery-access-systems@nottingham.ac.uk
Thumbnail Image

A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis

Publication Date
July 24, 2024
Creator
Abstract
Here, is presented a intramolecular [4+2] cycloaddition of a simply attained chiral allenecarboxanilide readily affords pseudoenantiomeric bicyclo[2.2.2]octa-2,5-dienes containing an alkenyl bromide, which can be readily functionalized to give diverse chiral diene ligands. The synthesis is straightforward and easily conducted on multigram scales. These ligands exhibit high performance in nine types of enantioselective Rh(I)-catalyzed 1,4-addition or 1,2-addition reactions, with up to 99% yield and >99% ee.
Item Type
ethesis
Thesis Type
PhD
Supervisors
Keywords

Asymmetric synthesis

Chiral compounds

metal catalysts

Subjects (LC)

QD Chemistry::QD241 O...

QD Chemistry::QD450 P...

Associated Schools / Departments
School of Chemistry
eprints ID
77486
UoN Repository URI
Except where otherwise noted, this item's license is described as
Thumbnail Image
Name

Synthesis of New Chiral Himbert Dienes as Ligand for Enantioselective Metal-Correction.pdf

Type

Full-text

Description
Examined
Size

7.87 MB

Format

Adobe PDF

Checksum (MD5)

c62d8c898a08b5028ea1ebcbb6dac689