Modelling angiogenesis in three dimensions
Publication Date
July 7, 2015
Creator
Abstract
The process through which new blood vessels are formed within the body is known as angiogenesis. An essential part of our survival, it has also been implicated more recently in many diseases both in terms of induced growth, and abnormal vascular structure.
Angiogenesis is characterized as two processes, the development of a vascular network during embryonic growth and the production of new blood vessels. This work focuses on the latter, and seeks to develop a robust, three-dimensional model for simulating blood vessel growth and the attendant processes of blood flow and mass transfer within the simulated system. A system was developed which utilises medical imaging scan data (specifically, MicroCT) as the initial conditions from which a network of vessels is grown. This is combined with GPU accelerated simulations of fluid dynamics, with the intention of providing a technique for future use in predictive medicine and therapeutic simulation.
Item Type
ethesis
Thesis Type
PhD
Supervisors
Associated Schools / Departments
School of Computer Science (UK)
eprints ID
29075
UoN Repository URI
Except where otherwise noted, this item's license is described as
File(s)![Thumbnail Image]()
Name
Modelling Angiogenesis in Three Dimensions.pdf
Type
Full-text
Description
Examined
Size
13.97 MB
Format
Adobe PDF
Checksum (MD5)
0a70dc121e4fb026b4a6287585091edf