Palladium and copper mediated cross couplings using dialkylphosphites
Publication Date
October 15, 2013
Creator
Abstract
Described herein are synthetic methodologies using palladium- and copper-mediated cross coupling reactions involving dialkylphosphites.
Chapter 1 discloses two methods for producing alknylphophonates. The first is a novel palladium mediated cross coupling of alkynylbromides with dialkylphosphites. The second is an improvement of a known aerobic copper mediated cross coupling using terminal alkynes and dialkylphosphites.
Chapter 2 discloses a novel aerobic copper mediated amide synthesis method.
Chapter 3 discloses a novel aerobic copper mediated phosphoramidate synthesis method.
All of the above developed methodologies were found to produce their respective products in acceptable yields and tolerate a wide range of functionality.
The experimental section comprises the practical methods for effecting the above reactions and the experimental data for all of the compounds presented herein.
Item Type
ethesis
Thesis Type
PhD
Supervisors
Associated Schools / Departments
School of Chemistry
eprints ID
13586
UoN Repository URI
Except where otherwise noted, this item's license is described as
File(s)![Thumbnail Image]()
Name
thesis_final_corrections.pdf
Type
Full-text
Description
Examined
Size
4.42 MB
Format
Adobe PDF
Checksum ()