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Immune-instructive polymers

Publication Date
May 1, 2020
Creators
Description
We identify polymers which instruct different immunological responses by modulating macrophage attachment and polarisation to pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. These immune-instructive polymers were discovered using in-vitro high throughput polymer microarray screening of diverse (meth)acrylate and (meth)acrylamide libraries. The bio-instructive polymer function is validated in-vivo and analysis of the protein layer adsorbed to polymers, cytokine release and phagocytosis explored.
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DOI
Associate publ. DOI
Subjects (LCSH)

Polymers

Regenerative medicine...

Macrophages

Immune response

Subjects

Bio-instructive mater...

Subjects (JACS)

Biological Sciences::...

Subjects (LC)

Q Science::QR Microbi...

Divisions
University of Nottingham, UK Campus
Data type
Excell spreadsheets, prism files, jpeg images, bmp image files, powerpoint document
Funders
Funders
EPSRC (Next Generation Biomaterials Discovery)
CiC Medical Research Council Grant
Grant Number
EP/N006615/1
Data collection method
Microscopy, cell profiler, XPS, proteomics gathering, ELISA, immuno staining
Resource languages
English
Publisher
The University of Nottingham
Date Issued
May 1, 2020
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Homo and Co-polymer microarrays data with Averages.xlsx

Description
Homo and co polymer array
Size

472.64 KB

Format

Microsoft Excel XML

Checksum (MD5)

1b1c4dbf3fd2337e0fe673424a2c867d

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Name

macrophage phenotype graph.pzfx

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48.93 KB

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Unknown

Checksum (MD5)

f0b2246d22c64906007fcdb3e87143de