Evaluating Modes of Influenza Transmission (EMIT) data files
Publication Date
May 14, 2020
Creators
Description
Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowledge gap. Healthy, seronegative volunteer ‘Donors’ (n=52) were randomly selected for intranasal challenge with influenza A/Wisconsin/67/2005 (H3N2). ‘Recipients’ randomized to Intervention (IR, n=40) or Control (CR, n=35) groups were exposed to Donors for four days. IRs wore face shields and hand sanitized frequently to limit large droplet and contact transmission. One transmitted infection was confirmed by serology in a CR, yielding a secondary attack rate of 2.9% among CR, 0% in IR (p=0.47 for group difference), and 1.3% overall, significantly less than 16% (p<0.001) expected based on a proof-of-concept study secondary attack rate and considering that there were twice as many Donors and days of exposure. The main difference between these studies was mechanical building ventilation in the follow-on study, suggesting a possible role for aerosols.
Coverage (Spatial):
UK volunteers
Collection dates:
March to June 2013
Subjects (LCSH)
Subjects (MeSH)
Subjects
Subjects (JACS)
Subjects (LC)
Divisions
University of Nottingham, UK Campus
University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences
University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicine
Corporate collaborators
H-Vivo plc.
Data type
Protocol, Data files, and analysis files
Funders
Funders
US CDC
Grant Number
1U01P000497-01
Data collection method
Protocol for human challenge study
Legal and ethical issues
written informed consent from healthy volunteers in accordance with the principles of the Declaration of Helsinki, in compliance with UK regulatory and ethical (IRB) requirements, and registered with ClinicalTrials.gov (number NCT01710111)
Resource languages
English
Publisher
The University of Nottingham
Date Issued
May 14, 2020
Except where otherwise noted, this item's license is described as
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