Raw data for new compounds described in the paper: "Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters"
Publication Date
May 22, 2018
Creators
Description
Raw data for new compounds described in the paper: "Enantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters". The enantioselective synthesis of highly functionalized chiral cyclopent-2-enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline–nickel complex, and cyclization is enabled by the reversible E/Z isomerization of alkenylnickel species. The general methodology is also applicable to the synthesis of 1,6-dihydropyridin-3(2H)-ones.
Associate publ. DOI
Subjects
Subjects (JACS)
Subjects (LC)
Divisions
University of Nottingham, UK Campus::Faculty of Science::School of Chemistry
Data type
IR, NMR, mass spectrometry, and HPLC data
Funders
European Union Horizon 2020 (Marie Sklowdowska-Curie Individual Fellowship)
University of Nottingham
GlaxoSmithKline
Grant Number
702386
EP/M506588/1
Data collection method
Using IR, NMR, and mass spectrometers, and HPLC machines
Resource languages
English
Publisher
The University of Nottingham
Date Issued
May 22, 2018
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Name
Ni-Cat Malonate Desymmetrization Raw Data.zip
Size
778.45 MB
Format
Unknown
Checksum (MD5)
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