Microparticles decorated with cell-instructive surface chemistries actively promote wound healing
Publication Date
November 18, 2022
Description
Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic non-healing wounds. Fibroblasts are a critical cell type involved in wound healing. We screened 315 different polymer surfaces to identify candidates which actively drove fibroblasts towards either pro- or anti-proliferative functional phenotypes. Fibroblast-instructive chemistries were identified, which we synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro-proliferative microfluidic derived particles were able to successfully promote neovascularisation, granulation tissue formation and wound closure after a single application to the wound bed. The data within this collection is associated with in vitro and in vivo assays carried out within the manuscript.
Subjects (LCSH)
Subjects
Subjects (JACS)
Subjects (LC)
Divisions
University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Life Sciences
Corporate collaborators
CicaBiomedical
Data type
Raw data for laboratory based experiments
Grant Number
EP/N006615/1
Data collection method
Data collection protocol
Resource languages
en_US
Publisher
The University of Nottingham
Date Issued
December 1, 2022
Except where otherwise noted, this item's license is described as
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