Design and evaluation of new quinazolin-4(3H)-one derived PqsR antagonists as quorum sensing quenchers in Pseudomonas aeruginosa
Publication Date
April 22, 2022
Creators
Description
A study focused on the design, synthesis and evaluation of pqs quorum sensing inhibitors
Collection dates:
2015/05 - 2020/12
Associate publ. DOI
Subjects (LCSH)
Subjects
Subjects (JACS)
Subjects (LC)
Divisions
University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Life Sciences
Data type
Crystallography files, Data analysis from reporter strain, imaging, and pyocyanin and LCMSMS analysis
Funders
JPIAMR
Grant Number
EP/N006615/1
EP/K005138/1
EP/N03371X/1
N501852/1
Data collection method
Molecular Docking, Mass spectrometry, NMR, Isothermal Calorimetry, Bioreporter assay, Alkyl quinolone quantification, pyocyanin quantification, PqsR protein expression, Galleria Mellonella survival assay, Microscopy and biofilm formation assay
Resource languages
English
Publisher
The University of Nottingham
Date Issued
April 22, 2022
Except where otherwise noted, this item's license is described as
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Name
Exp_1_.zip
Size
1.83 MB
Format
Unknown
Checksum (MD5)
5418962af7896a12db49ccd40c6433e9