Prediction of broad spectrum pathogen attachment to coating materials for biomedical devices data
Publication Date
December 21, 2018
Description
Bacterial infections in healthcare settings are a frequent accompaniment to both routine procedures such as catheterization and surgical site interventions. Their impact is becoming even more marked as the numbers of medical devices that are used to manage chronic health conditions and improve quality of life increases. The resistance of pathogens to multiple antibiotics is also increasing, adding an additional layer of complexity to the problems of employing safe and effective medical procedures. One approach to reducing the rate of infections associated with implanted and indwelling medical devices is the use of polymers that resist the formation of bacterial biofilms. To significantly accelerate the discovery of such materials, we show how state of the art machine learning methods can generate quantitative predictions for the attachment of multiple pathogens to a large library of polymers in a single model for the first time. Such models facilitate design of polymers with very low pathogen attachment across
different bacterial species that will be candidate materials for implantable or indwelling medical devices such as urinary catheters, cochlear implants and pacemakers.
Associate publ. DOI
Subjects
Divisions
University of Nottingham, UK Campus::Faculty of Science::School of Pharmacy
Data type
Datasets
Grant Number
EP/N006615/1
085245
Data collection method
GenePix Autoloader 4200AL
Resource languages
English
Publisher
The University of Nottingham
Date Issued
December 21, 2018
File(s)![Thumbnail Image]()
Name
Broadspectrum_paper_data.zip
Size
8.58 MB
Format
Unknown
Checksum (MD5)
ae96e06e97aa0c27d4d56ad0bd84ce86